Similac Alimentum VS Enfamil Nutramigen: Selecting the Ideal Formula for Your Infant

baby formula

In the journey of parenthood, ensuring your baby’s health and happiness is paramount, and choosing the right infant formula plays a crucial role. Especially if your little one is grappling with colic, acid reflux, or lactose allergies, selecting the perfect formula that supports their digestion and nutritional requirements can be quite challenging.

Among various options available, Similac Alimentum and Enfamil Nutramigen are widely recognized for their benefits, particularly for babies dealing with colic, allergies, or acid reflux. To guide you in making an informed choice, we delve into a comprehensive analysis of these two prominent formulas, discussing their pros, cons, and noteworthy features.

Comparing the Products

To identify the best fit for your infant, it’s crucial to juxtapose Similac Alimentum and Enfamil Nutramigen. Although they share many similarities, their unique differences might influence your decision. Let’s dissect each product’s details, accentuating their advantages and potential drawbacks.

Similac Alimentum

similac alimentum

It is a hypoallergenic baby formula tailored for babies suffering from colic, acid reflux, gas, and allergies. The pre-digested proteins in the formula are gentle on the baby’s digestive system, making it easy to digest. Available in both powdered and ready-to-feed versions, this formula can be conveniently found in most stores selling baby formulas.


  • Pre-digested proteins facilitate digestion, reducing gas and spit-up post-feeding.
  • Similac is a highly reputable brand, often recommended by pediatricians.
  • The formula typically improves the baby’s digestion within approximately 48 hours.
  • Available in two formats: powdered and ready-to-feed.


  • The pre-digested formula may not be palatable for babies used to breastmilk or traditional formulas.
  • Compared to other options, Alimentum tends to be more expensive for regular feeding.
  • The formula isn’t intended to replace all other nutritional sources.
  • For breastfeeding babies, switching between breastmilk and formula could be difficult.

Intended Audience


It is ideal for families with babies who have sensitive digestive systems, colic, acid reflux, gas, or allergies such as lactose intolerance. It’s designed as a supplementary formula rather than a complete substitute for other formulas or breastmilk.

Key Features and Benefits

The primary advantage of Similac Alimentum is its pre-digested formula, which eases digestion for babies. Especially for those suffering from colic, gas, or allergies, this formula reduces strain on the digestive system while providing necessary proteins.


Similac Alimentum can be a suitable choice for parents seeking hypoallergenic formulas for their babies. It caters to the immediate nutritional needs of the baby while being gentle on their digestive system. However, its taste might be unappealing, and it isn’t a complete replacement for other feeding methods.

Enfamil Nutramigen


Enfamil Nutramigen, another hypoallergenic formula fortified with iron, is tailored for babies with gas, colic, acid reflux, upset stomach, or lactose intolerance/allergies. Available in both powder and ready-to-feed formats, this formula is easily accessible in stores selling infant formulas.


  • Dairy- and soy-free formula.
  • Enfamil is a reputable brand endorsed by numerous pediatricians.
  • Provides the required vitamins and nutrients for infant health.
  • Generally improves baby’s digestion within approximately 48 hours.
  • Also available in powder and ready-to-feed formats.
  • Contains additional DHA for brain development.
  • Includes probiotics to promote gut health.


  • Like Alimentum, Nutramigen is expensive for regular feeding.
  • The hypoallergenic nature alters the taste, which might be unpalatable for your baby.
  • Transitioning between breast milk and formula could be challenging for breastfeeding babies.

Intended Audience

Baby Formula eating

Enfamil Nutramigen is designed for families with infants having sensitive digestive systems, colic, acid reflux, gas, or allergies like lactose intolerance. This formula encompasses all the vitamins and nutrients essential for an infant’s growth and well-being.

Key Features and Benefits

It is distinguished by its soy- and dairy-free composition, reducing potential allergic reactions in babies. Despite the exclusion of these ingredients, the formula delivers all vital nutrients, ensuring the baby’s healthy growth.


Enfamil Nutramigen is a potent hypoallergenic substitute for conventional formulas. While providing essential nutrients and vitamins, it’s also dairy- and soy-free, lowering the risk of allergic reactions. However, the taste might be off-putting, making it hard for your baby to drink.



If neither Similac Alimentum nor Enfamil Nutramigen suits your baby, there are other hypoallergenic infant formulas worth considering that will make your baby full and happy. For instance, Gerber Extensive HA is a renowned alternative specifically tailored for babies allergic to cow’s milk protein. Only available in powdered form, this formula offers comprehensive nutrients for a baby’s healthy growth and utilizes 100% whey protein for easier digestion. Its pricing aligns closely with other Gerber formulas.


Do Similac Alimentum and Enfamil Nutramigen taste different than regular formulas?

Due to the process of breaking down the proteins, hypoallergenic formulas often have a slightly different taste than regular formulas. Some infants might initially refuse or be fussy about the new formula, but most will adapt to the change in flavor over time.

Are there any nutritional differences between Similac Alimentum and Enfamil Nutramigen?

Both formulas are designed to provide complete nutrition for your baby. The main difference is in the protein source and how it’s processed. It’s always important to check the label to understand the specific nutrients each formula offers.

Can I use Similac Alimentum or Enfamil Nutramigen if my baby is lactose intolerant?

Yes. Both Similac Alimentum and Enfamil Nutramigen are lactose-free, making them suitable for infants who are lactose intolerant.

Can I feed my baby Similac Alimentum or Enfamil Nutramigen if they don’t have a protein allergy?

While these formulas are designed for babies with protein sensitivities, they can still be used for babies without these issues. However, due to their higher cost and different taste, many parents choose regular formula if their baby can tolerate it.

Are Similac Alimentum and Enfamil Nutramigen suitable for preterm infants?

While both formulas can generally be used for preterm infants, it’s essential to consult with your healthcare provider as preterm infants often have specific nutritional needs.

Can I mix breast milk with Similac Alimentum or Enfamil Nutramigen?

Yes, you can mix breast milk with these formulas. However, if your baby is sensitive to the proteins in cow’s milk, they may also react to the same proteins in your breast milk if you consume dairy products.

What should I do if my baby refuses to drink Similac Alimentum or Enfamil Nutramigen?

It’s not uncommon for babies to initially resist a new formula due to the change in taste. You can try gradually introducing the new formula by mixing it with the old one and slowly increasing the amount. If your baby continues to refuse the formula, consult with your pediatrician.

Final Verdict

Similac Alimentum and Enfamil Nutramigen, both recognized for their effectiveness as hypoallergenic formulas, show several similarities, including a higher cost compared to traditional formulas and other hypoallergenic alternatives.

Nonetheless, Enfamil Nutramigen edges out Similac Alimentum by including probiotics, which aid in fostering gut health and early digestive health. Nutramigen also has a higher DHA content than Alimentum.

Considering these features, it’s advisable for parents to start with Enfamil Nutramigen. It provides better overall nutrients for the baby’s health. However, if Nutramigen doesn’t sit well with the baby or fails to support their growth, Similac Alimentum stands as a reliable alternative.